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It starts to raise cellular levels in 30 minutes, well within the "window of therapy"

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For example, although the relationship between P53 and ferroptosis has been well established[88, 211, 212], there is no evidence suggesting that its methylation is involved in the regulatory effect of P53 on ferroptosis

Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes

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